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Home  >  Journal list  >  Journal of the Ceramic Society of Japan  >  Vol.117  No.1365 (May) (2009)  >  pp.543-549

Journal of the Ceramic Society of Japan
<<Previous article Vol.117  No.1365 (May) (2009)   pp.543 - 549 Next article>>

Biocompatible ceramic nanocarrier for drug delivery with high efficiency

Soo-Jin CHOI1)2), Jae-Min OH1)3) and Jin-Ho CHOY1)
1) Center for Intelligent Nano-Bio Materials, Division of Nano Sciences BK21, Department of Bioinspired Science and Department of Chemistry and Nano Science, Ewha Womans University
2) Department of Food Science and Technology, Seoul Women's University
3) Department of Chemistry and Medical Chemistry, Yonsei University


  Layered double hydroxides, a class of anionic nanoclays, have emerged as drug delivery carriers characterized by an effective uptake mechanism via clathrin-mediated endocytosis and high reservoir capacity. In the present review, the efficacy of an anticancer drug with ceramic nanocarriers, i.e. layered double hydroxides, is discussed in context of the cellular uptake mechanism in cell culture lines and pharmacokinetic and tissue distribution studies in whole animals. In addition, research results on the biodistribution patterns of only fluorescently labeled layered double hydroxides and the subsequent histopathological analysis are described in detail to assess the biocompatibility of layered double hydroxides in vivo. The determination of relationships between delivery efficiency and toxicity can be useful for the rational development of layered double hydroxides as drug delivery systems.


Keyword:
Layered double hydroxide, Drug delivery system, Efficacy, Toxicity, Biocompatibility

Received: March 12, 2009
Published online: May 01, 2009
Copyright (c) 2009 The Ceramic Society of Japan

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