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Home  >  Journal list  >  MATERIALS TRANSACTIONS  >  Vol.42  No.12 (2001)  >  pp.2590-2596

<<Previous article Vol.42  No.12 (2001)   pp.2590 - 2596 Next article>>

Biocompatibility of Surface-Treated Pure Titanium and Ti-6Al-4V Alloy

Byung Il Kim1), Min Ho Lee2), Woo Yong Chon2), Dong Joo Yoon3), Tae Sung Bae4), Hyeoung Ho Park5) and Hyun Wook Cho6)
1) Department of Materials Science and Metallurgical Engineering, Sunchon National University
2) Department of Iron and Metallurgical Engineering, Kwangyang College and Hientct Co. Ltd.
3) Department of Advanced Material Engineering, Hanlyo University
4) Department of Dental Materials, Chonbuk National University
5) Korea Research Institute of Rare Metals
6) Department of Biology, Sunchon National University

In the present study, commercial purity Ti and Ti–6Al–4V alloy specimens with and without alkali- and heat-treatments were implanted in the abdominal connective tissue of mice. Conventional SUS 316L stainless steel was also implanted for comparison. After three months, their biocompatibility was evaluated by in vitro and in vivo experiments. When immersed in Hank’s solution, which has ion concentrations similar to that of human blood, an apatite layer, which accelerates the connection with bone, formed easily on the alkali-treated specimens compared to the non-treated specimens. The number of macrophages, which is known to increase as the inflammation reaction proceeds, is much lower for the alkali-treated specimens than for other samples. The average thickness of the fibrous capsule formed around the implant is much thinner for the alkali-treated specimens than for the others. These results show that the alkali- and heat-treatments performed in the present study will be very effective for the improvement of biocompatibility.

apatite, biocompatibility, mouse abdominal connective tissue, macrophages

Received: April 10, 2001
Accepted: October 19, 2001 , Published online: September 06, 2005
Copyright (c) 2005 The Japan Institute of Metals



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