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Home  >  Journal list  >  Polymer Journal  >  Vol.45  No.3 (2013)  >  pp.331-338

Polymer Journal
<<Previous article Vol.45  No.3 (2013)   pp.331 - 338 Next article>>

Synthesis, characterization and applications of amphiphilic elastomeric polyurethane networks in drug delivery

Pablo Christian Caracciolo1, Cristina Sanz Pita2, Gustavo Abel Abraham1, José Alberto Méndez2 and Jordi Gironès Molera3
1Instituto de Investigaciones en Ciencia y Tecnología de Materiales, INTEMA (UNMdP-CONICET), Mar del Plata, Argentina
2Lepamap Group, Universitat de Girona, Campus Montilivi, Girona, Spain
3Nanomateriales Poliméricos y Biomateriales, Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Madrid, Spain

Polyurethanes have a key role in the development of many different biomedical devices because of their exceptional biocompatibility, mechanical properties and versatility. Although linear segmented polyurethanes have been extensively studied, the investigation of cross-linked polyurethanes remains limited. In this work, three series of polyurethane networks were synthesized by reacting poly(ethylene glycol) and hexamethylene diisocyanate with either tetrafunctional poloxamer Tetronic 701 or poly(ε-caprolactone)s triol with molecular weights of 1060 and 3130Da. The hydrophilic/hydrophobic ratio was varied by selecting the appropriate amounts of monomers, and its effects on the swelling behavior and the thermal properties were analyzed. Studies concerning the release of a model drug were performed, the results of which indicate that these materials hold promise for use in controlled implantable drug-delivery devices and antimicrobial coatings.


Keyword:
controlled drug release; hydrophilic/hydrophobic ratio; polyurethane networks; swelling behavior; thermal properties

Received: March 05, 2012 , Revised: April 25, 2012
Accepted: May 03, 2012 , Published online: July 04, 2012
© 2013 The Society of Polymer Science, Japan

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