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Home  >  Journal list  >  Journal of the Ceramic Society of Japan  >  Vol.124  No.12 (December) (2016)  >  pp.1199-1204

Journal of the Ceramic Society of Japan
<<Previous article Vol.124  No.12 (December) (2016)   pp.1199 - 1204 Next article>>

In vivo evaluation of wound healing property of zinc smectite using a rat model

Yu SASAKI1), Gulsan Ara SATHI1), Osamu YAMAMOTO1)
1) Bio-engineering, Graduate School of Science and Engineering, Yamagata University

Zinc, magnesium and silicon ions are known as bioactive ions that promote the hard and soft tissue regeneration. We hypothesized that Zn-smectite consisting of zinc and silicon ions provide a more potential biomaterial in regenerative medicine field. Zn-smectite powder was thus synthesized in this study and used for wound healing. The aim of the present work was to evaluate the effect of Zn-smectite on wound healing in rats. An aqueous solution was prepared by dissolving zinc chloride (ZnCl2) and water glass in distilled water, and then refluxed at 90°C for 12 h; after which crystalline Zn-smectite powder was obtained. The amount of Zn2+ and Si4+ ions releasing from Zn-smectite in physiological saline was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). It was observed that the amount of the Zn2+ ion released from the Zn-smectite powder increased with the soaking time, but the released amount of Si4+ ion decreased with the soaking time. To evaluate the biofunctional ability, Zn-smectite was applied to a full thickness surgical wound created in the rat’s abdomen. In the results for skin regeneration, there was no significant difference in wound size between the control and Zn-smectite group at 1 and 2 weeks. However, it was observed that Zn-smectite promoted greater vascular regeneration and more skin appendages in comparison with the control. Zn-smectite can be expected to stimulate wound healing and heal the tissue close to the native tissue by releasing Zn2+ and Si4+ ions, suggesting that this newly formed material could offer greater potentiality in the field of regenerative medicine.


Keyword:
Zn-smectite, Powder, Ion release, Angiogenesis, Wound healing

Received: July 08, 2016
Accepted: September 24, 2016 , Published online: December 01, 2016

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