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Home  >  Journal list  >  Polymer Journal  >  Vol.19  No.12 (1987)  >  pp.1329-1339

Polymer Journal
<<Previous article Vol.19  No.12 (1987)   pp.1329 - 1339 Next article>>

Synthesis, Blood Compatibility, and Gas Permeability of Block Copolymers Consisting of Polyoxypropylene and Poly(γ-benzyl L-glutamate)

Inn-Kyu Kang1), Yoshihiro Ito1), Masahiko Sisido2) and Yukio Imanishi1)
1) Department of Polymer Chemistry, Faculty of Engineering, Kyoto University
2) Research Center for Medical Polymers and Biomaterials, Kyoto University


ABSTRACT:  A-B-A-type block copolymers were prepared by the polymerization of γ-benzyl L-glutamate NCA (A segment) using polyoxypropylene (POP, B segment) with amino groups at both ends of a chain as an initiator. Thrombus formation on the block copolymer films was minimum on a block copolymer containing a POP segment of 50 mol%. It was found that on the block copolymer, denaturation of plasma proteins such as albumin and fibrinogen upon adsorption was sufficiently low not to activate adhered platelets, leading to a low degree of thrombogenesis. The oxygen permeation coefficients (P) of block copolymer films in water were about twice as large as that of poly(γ-benzyl L-glutamate) (PBLG) film. The increased permeation was ascribed to an increased diffusion coefficient (D) of dissolved oxygen through the block copolymer films. Arrhenius plots of P and D showed a break point in the temperature range of 20–30°C. At lower temperatures than the break temperature, the activation energy for oxygen permeation of the block copolymer film was lower than that of PBLG film.


Keyword:
Block Copolymer/ Poly(γ-benzyl L-glutamate)/ Poly-oxypropylene/ Thrombogenesis/ Oxygen Permeation/ Plasma Protein/ Platelet

Published online: April 08, 2005
© Copyright, 2005 by The Society of Polymer Science, Japan

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