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Home  >  Journal list  >  Polymer Journal  >  Vol.22  No.10 (1990)  >  pp.867-874

Polymer Journal
<<Previous article Vol.22  No.10 (1990)   pp.867 - 874 Next article>>

Polymerization of Liposomes Evaluated from Molecular Weight Distribution of Diene-Type Phospholipid Polymers

Shinji Takeoka1), Noboru Kimura1), Hiroyuki Ohno1) and Eishun Tsuchida1)
1) Department of Polymer Chemistry, Waseda Univesity

ABSTRACT:  1,2-Bis(2,4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (DODPC) or 1-palmitoyl-2-(2,4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (POPC) was dispersed in water by sonication to form liposomes. DODPC liposomes were polymerized by UV-irradiation or with radical initiator such as azobis(2-amidinopropane)dihydrochloride (AAPD) at 60°C and methanolyzed to obtain THF-soluble polymers. The molecular weight distribution obtained from a gel permeation chromatography reveals that the UV-irradiation provides low-molecular-weight products and a small amount of polymers, while free radical polymerization gives polymers having relatively high-molecular-weight. The molecular weight of the phospholipid polymers is also influenced by the assembling state. The constrained lipid packing of small unilamellar POPC liposomes provides relatively low-molecular-weight polymers in comparison with those of larger liposomes. In addition, POPC liposomes polymerized at the temperature above the gel-to-liquid crystalline phase transition temperature (Tc) show the higher molecular weight of polymers than those polymerized below the Tc.


Keyword:
Diene-Containing Phospholipid/ Liposomes/ Molecular Weight Distribution/ Polymerization/ UV-Irradiation/ Radical Initiator/ Lipid Packing/ Phase Transition Temperature

Published online: April 06, 2005
© Copyright, 2005 by The Society of Polymer Science, Japan

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