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Home  >  Journal list  >  Journal of the Society of Materials Science, Japan  >  Vol.55  No.4 (2006)  >  pp.391-396

Journal of the Society of Materials Science, Japan
<<Previous article Vol.55  No.4 (2006)   pp.391 - 396 Next article>>

Characterization of Thermo-Responsive Poly [N- (2-Hydroxypropyl) Methacrylamide–Dimethylsiloxane] Block Copolymers

Nobuyuki TANIGAWA1), Kohei SHIRAISHI2) and Kazuo SUGIYAMA2)
1) Res. Lab., Manac Incorporated
2) Cluster of Biotech. and Chem. Systems, Graduate School of Systems Eng., Kinki Univ.


Block copolymers, Poly (HPMA-b-DMS)-1∼7, were obtained from polymerization of N- (2-hydroxypropyl) methacrylamide (HPMA) initiated with polydimethylsiloxane (PDMS) type of azo-initiator [4,4’-azobis (polydimethylsiloxane)-4-cyanopentanoate (azo-PDMS)]. From XPS measurements of freeze dried samples, the hydrophilic PHPMA segment was found to migrate to the surface of Poly (HPMA-b-DMS) films in water. Poly (HPMA-b-DMS) showed lower contact angle (θ = 54°∼100°) than PDMS itself (θ = 103°). It was also found that the contact angle of block copolymers was changed in response to change in temperature, i.e., θ = 64°∼79° at 40°C and θ = 54°∼69° at 20°C for Poly (HPMA-b-DMS). The amount of adsorption of albumin on the Poly (HPMA-b-DMS) film was depressed at 20°C compared to the case at 40°C. For the purpose of an application to a thermo-responsive drug delivery system, copolymer hydrogel Gel (HPMA-b-DMS) was also prepared by radical copolymerization of HPMA and N,N’-ethylenebisacrylamide initiated with azo-PDMS.


Keyword:
Block copolymers, Polydimethylsiloxane, N- (2-Hydroxypropyl) methacrylamide, Thermo-responsive, Copolymer hydrogel, Swelling-shrinking change

Received: September 28, 2005
Published online: May 17, 2006
Copyright (c) 2006 by The Society of Materials Science, Japan

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