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Home  >  Journal list  >  Journal of the Ceramic Society of Japan  >  Vol.121  No.1409 (January) (2013)  >  pp.68-73

Journal of the Ceramic Society of Japan
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Properties of novel bone hemostat prepared using hydroxyapatite, phosphoryl oligosaccharides of calcium and thermoplastic resin

Tokio MIMURA1), Tomohiro UMEDA1), Yoshiro MUSHA2), Kiyoshi ITATANI1)
1) Department of Materials and Life Sciences, Faculty of Science and Engineering, Sophia University 2) 2 Department of Orthopaedic Surgery, School of Medicine, Toho University

A novel hemostatic agent was prepared using phosphoryl oligosaccharides of calcium (POs-Ca), hydroxyapatite [Ca10(PO4)6(OH)2; HAp] obtained by the hydrolysis of POs-Ca (i.e., sugar-containing HAp (s-HAp), Ca/P ratio = 1.56, 60.3 mass% calcium-deficient HAp and 39.5 mass% organic materials) and thermoplastic resin (random copolymer of ethylene oxide and propylene oxide; EPO). The gel formed by mixing the EPO with water (EPO/water mass ratio: 0.20) was flash frozen at −80°C and then freeze-dried at −50°C for 15 h. The freeze-dried material was blended with POs-Ca or s-HAp. The hemostat, whose consistency had been adjusted to that of commercial hemostat by adding water, possessed the stanching times: 6.0 h (s-HAp/EPO hemostat; s-HAp/EPO = 0.20) > 5.75 h (POs-Ca/EPO hemostat; POs-Ca/EPO = 0.20) > 4.75 h (EPO hemostat). The test for the implantation of these composite hemostats into the Japanese white rabbits indicated that the bone regeneration of s-HAp/EPO composite hemostat was excellent, compared to the case of POs-Ca/EPO composite hemostat. The loading of gentamicin, a typical antibiotic agent, to the s-HAp/EPO composite hemostat showed the steady state releasing in the phosphate buffered saline.

Bone hemostat, Hydroxyapatite, Phosphoryl oligosaccharides of calcium, Thermoplastic resin, Drug releasing properties

Received: July 12, 2012
Accepted: October 29, 2012 , Published online: January 01, 2013
Copyright © 2013 The Ceramic Society of Japan



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